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cgrp receptor antagonist bibn4096bs  (Haoyuan Chemexpress Co Ltd)
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CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist <t>BIBN4096BS.</t> Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).
Cgrp Receptor Antagonist Bibn4096bs, supplied by Haoyuan Chemexpress Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecule cgrp receptor antagonist rimegepant  (Selleck Chemicals)
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CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist <t>BIBN4096BS.</t> Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).
Small Molecule Cgrp Receptor Antagonist Rimegepant, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cgrp receptor antagonists  (Boehringer Ingelheim)
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CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist <t>BIBN4096BS.</t> Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).
Cgrp Receptor Antagonists, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cgrp receptor antagonist platform  (Bristol Myers)
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CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist <t>BIBN4096BS.</t> Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).
Cgrp Receptor Antagonist Platform, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist BIBN4096BS. Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).

Journal: Frontiers in Cell and Developmental Biology

Article Title: CGRP-mediated neuro-vascular-pulp cell crosstalk is essential for dental pulp repair

doi: 10.3389/fcell.2026.1793692

Figure Lengend Snippet: CGRP Promotes Angiogenesis in HUVECs and Pulp Repair via Upregulation of CD31/VEGFA (A) Representative images of tube formation assays using HUVECs treated with or without CGRP. Scale bar, 500 µm. (n = 3, *p < 0.05, **p < 0.01 vs. NC group). (B) ​ Representative images of scratch wound healing assays of HUVECs at 0,12 and 24 h post-CGRP treatment and quantitative analysis of wound closure rate. Scale bar, 100 µm. (n = 3, *p < 0.05 vs. NC group). (C) ​ qRT-PCR and Western blot analysis of CD31 and VEGFA levels in HUVECs. (n = 3, **p < 0.01, ***p < 0.001 vs. NC group). (D) ​ Representative immunofluorescence images showing CD31 + blood vessels (red) in the injured pulp region of mice treated with either vehicle (NC) or the CGRP receptor antagonist BIBN4096BS. Nuclei are counterstained with DAPI (blue). Scale bar, 50 µm. Green dashed line, dentin injury (cavity). Green arrow, region of interest (ROI) in the pulp horn beneath the injury site, where vascular changes were analyzed. (E) ​ CGRP-activated endothelial cells promote the mineralization of DPSCs via a paracrine mechanism. (n = 3, **p < 0.01vs. NC group).

Article Snippet: The CGRP receptor antagonist BIBN4096BS was purchased from Shanghai Haoyuan Chemexpress Co. (Shanghai, China).

Techniques: Quantitative RT-PCR, Western Blot, Immunofluorescence